Genetic basis of multiple sclerosis

Principal Investigator
Maja Živković, PhD, Full Research Professor 

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with a high prevalence of 0.1% in the general population. It is a complex disease of multifactorial etiology both genetic as well as environmental. Classical genetic studies of familial forms of MS and MS twins suggest polygenic basis of disease, where a large number of genes acting independently or epistatic.
Our group deals with the molecular genetic analysis of candidate genes to tests their contributions to the predisposition to MS and the different forms of the disease (relapsing-remitting, secondary-progressive and primary progressive). 
Experimental approach: The SNP analysis; Association of SNPs with gene expression; The haplotype analysis; The association of haplotypes with gene expression. Micro RNA analysis. The whole genome analysis on microarray scanner: Whole genome expression analysis; GWAS for SNPs, whole genome methylation analysis 
The case-control and case-case design for human studies. Strong collaboration with clinicians.

Publications:

1.    Živković M, Kolaković A, Stojković L, Dinčić E, Kostić S, Alavantić D, Stanković A. Renin-angiotensin system gene polymorphisms as risk factors for multiple sclerosis. J Neurol Sci. 2016 Apr 15;363:29-32.
2.    Stojković L, Stanković A, Djurić T, Dinčić E, Alavantić D, Zivković M. The gender-specific association of CXCL16 A181V gene polymorphism with susceptibility to multiple sclerosis, and its effects on PBMC mRNA and plasma soluble CXCL16 levels: preliminary findings. J Neurol. 2014 Aug;261(8):1544-51.
3.    Zivković M, Starčević Čizmarević N, Lovrečić L, Klupka-Sarić I, Stanković A, Gašparović I, Lavtar P, Dinčić E, Stojković L, Rudolf G, Jazbec SS, Perković O, Sinanović O, Sepčić J, Kapović M, Peterlin B, Ristić S. The role of TPA I/D and PAI-1 4G/5G polymorphisms in multiple sclerosis. Dis Markers. 2014;2014:362708.
4.    Živković M, Životić I, Dinčić E, Stojković L, Vojinović S, Stanković A. The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis. J Neurol Sci. 2013 Nov 15;334(1-2):6-9.
5.    Krsmanović Ž, Živković M, Lepić T, Stanković A, Raičević R, Dinčić E. Small internal jugular veins with restricted outflow are associated with severe multiple sclerosis: a sonographer-blinded, case-control ultrasound study. BMC Neurol. 2013 Jul 17;13:90.
6.    Stojković L, Djurić T, Stanković A, Dinčić E, Stančić O, Veljković N, Alavantić D, Zivković M. The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis. J Neuroimmunol. 2012 Apr;245(1-2):87-92.
7.    Stanković A, Dincić E, Ristić S, Lovrecić L, Starcević Cizmarević N, Djurić T, Sepcić J, Kapović M, Raicević R, Peterlin B, Alavantić D, Zivković M. Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans. Mult Scler. 2010 May;16(5):533-6
8.    Zivković M, Stanković A, Dincić E, Popović M, Popović S, Raicević R, Alavantić D. The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: cost-effective high-throughput detection by real-time PCR. Clin Chim Acta. 2009 Aug;406(1-2):27-30.
9.    Djurić T, Zivković M, Stanković A, Dincić E, Raicević R, Alavantić D. Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia. J Neurol Sci. 2008 Apr 15;267(1-2):62-5.
10.    Zivković M, Djurić T, Dincić E, Raicević R, Alavantić D, Stanković A. Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. J Neuroimmunol. 2007 Sep;189(1-2):147-50.
11.    Dincić E, Zivković M, Stanković A, Obradović D, Alavantić D, Kostić V, Raicević R. Association of polymorphisms in CTLA-4, IL-1ra and IL-1beta genes with multiple sclerosis in Serbian population. J Neuroimmunol. 2006 Aug;177(1-2):146-50.

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