Genetic basis of atherosclerosis

Principal Investigator
Maja Živković, PhD, Full Research Professor

Atherosclerosis can cause stroke or myocardial infarct. Research in our Lab aims to identify genetic, epigenetic and environmental risk factors that promote atherosclerosis in order to improve prevention, identify molecular and cellular pathways that may be targeted therapeutically. We critically evaluate the role of genotype as a tool for prediction of disease risk and drug response. The approach is integrative, interdisciplinary and collaborative.


Publications:

1.    Djordjevic A, Dekleva M, Zivkovic M, Stankovic A, Markovic Nikolic N, Alavantic D, Djuric T. Left ventricular remodeling after the first myocardial infarction in association with LGALS-3 neighbouring variants rs2274273 and rs17128183 and its relative mRNA expression: a prospective study. Mol Biol Rep. 2018. doi: 10.1007/s11033-018-4384-4. 
2.    Zivotić I, Djurić T, Stanković A, Ivančević I, Končar I, Milasinovic D, Stankovic G, Alavantić D, Zivković M. The HACD4 haplotype as a risk factor for atherosclerosis in males. Gene. 2018 Jan 30;641:35-40.
3.    Djordjevic A, Zivkovic M, Stankovic A, Zivotic I, Koncar I, Davidovic L, Alavantic D, Djuric T. Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study. J Clin Lab Anal. 2016 Nov;30(6):1150-1157.
4.    Kolaković A, Stanković A, Djurić T, Živković M, Končar I, Davidović L, Radak D, Alavantić D.
Gender-Specific Association between Angiotensin II Type 2 Receptor -1332 A/G Gene Polymorphism and Advanced Carotid Atherosclerosis. J Stroke Cerebrovasc Dis. 2016 Jul;25(7):1622-1630.
5.    Stanković A, Kolaković A, Živković M, Djurić T, Bundalo M, Končar I, Davidović L, Alavantić D. Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques. Atherosclerosis. 2016 May;248:132-9.
6.    Zivotić I, Djurić T, Stanković A, Djordjević A, Končar I, Davidović L, Alavantić D, Zivković M. 9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner. Exp Biol Med (Maywood). 2016 Jun;241(11):1210-6.
7.    Jovanović I, Zivković M, Djurić T, Popović M, Alavantić D, Stanković A. CXCL16 in Vascular Pathology Research: from Macro Effects to microRNAs. J Atheroscler Thromb. 2015;22(10):1012-24.
8.    Jovanović I, Zivković M, Jovanović J, Djurić T, Stanković A. The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. Med Hypotheses. 2014 Jul;83(1):11-5.
9.    Zurnić I, Djurić T, Koncar I, Stanković A, Dincić D, Zivković M. Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis. Vojnosanit Pregl. 2014 Apr;71(4):362-7.
10.    Zivković M, Stanković A, Djurić T, Končar I, Kolaković A, Djurdjević V, Davidović L, Alavantić D. Effects of glutathione S-transferase T1 and M1 deletions on advanced carotid atherosclerosis, oxidative, lipid and inflammatory parameters. Mol Biol Rep. 2014 Feb;41(2):1157-64.
11.    Djurić T, Stojković L, Zivković M, Končar I, Stanković A, Djordjević A, Alavantić D. Matrix metalloproteinase-1 promoter genotypes and haplotypes are associated with carotid plaque presence. Clin Biochem. 2012 Nov;45(16-17):1353-6.
12.    Zivković M, Kolaković A, Radak D, Dinčić D, Radak S, Djurić T, Stanković A. The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study. Mol Biol Rep. 2012 Jun;39(6):6479-85.
13.    Kolaković A, Zivković M, Radak D, Djurić T, Koncar I, Davidović L, Dincić D, Alavantić D, Stanković A. The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy. J Renin Angiotensin Aldosterone Syst. 2012 Mar;13(1):141-7.
14.    Djurić T, Stanković A, Končar I, Radak D, Davidović L, Alavantić D, Živković M. Association of MMP-8 promoter gene polymorphisms with carotid atherosclerosis: preliminary study. Atherosclerosis. 2011 Dec;219(2):673-8.
15.    Djurić T, Zivković M, Stanković A, Kolaković A, Jekić D, Selaković V, Alavantić D.
Plasma levels of matrix metalloproteinase-8 in patients with carotid atherosclerosis. J Clin Lab Anal. 2010;24(4):246-51.
16.    Djurić T, Umićević M, Koncar I, Zivković M, Vasić D, Davidović L, Stanković A, Alavantić D. Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population. Clin Chem Lab Med. 2009;47(12):1573-5.
17.    Djurić T, Zivković M, Radak D, Jekić D, Radak S, Stojković L, Raicević R, Stanković A, Alavantić D. Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis. Clin Biochem. 2008 Nov;41(16-17):1326-9.
18.    Zivković M, Djurić T, Stancić O, Alavantić D, Stanković A. X-linked angiotensin II type 2 receptor gene polymorphism -1332A/G in male patients with essential hypertension. Clin Chim Acta. 2007 Nov-Dec;386(1-2):110-3.
19.    Dincić D, Zivković M, Stanković A, Djurić T, Vujanić S, Gligić B, Alavantić D. Apolipoprotein(a) gene polymorphisms (TTTTA)n and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia. Wien Klin Wochenschr. 2005 Jun;117(11-12):406-11.

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